In their two ties they drew 1-1 in Pretoria and then Wydad edged Sundowns 1-0 in Rabat.
Sundowns coach Pitso Mosimane admits that the battles against Wydad have been tight and bruising affairs.
"They know how to win a match. They know how to get a result, and always take a point from us," Mosimane said.
"Last year, due to our mistake, they stole a point from us [in 1-1 draw] but the previous year we beat them. Their fans are always a sea of red, 70,000 people at the stadium.
"Against them we need to play with speed. They are big boys and have the right technique. We need the interplay and to push the ball in between the lines."
As the big match looms, the eight-time Absa Premiership champions look to bounce back from their 2-1 loss to Lobi Stars last weekend.
Mosimane will rely on the sage-heads in his team to deliver a positive result.
"We need Gaston Sirino on form; we need Themba Zwane on form. Guys like Lebo Maboe, he's young and works hard, but you need guys who have been there."