His comments were greeted by loud cheers from women activists and members of nongovernmental organisations against gender-based violence.
He also said there was a need for the government to investigate harmful religious and cultural practices that lead to the exploitation of women and children.
"We commit ourselves in this declaration to commit, to resource, [and to] strengthen the existing gender machinery," said the president, adding that the survivors of gender-based violence need to be treated with fairness, respect, dignity and privacy. "Today begins a new era in our determined struggle to rip our society off gender-based violence and femicide."
Ramaphosa and acting premier, education MEC Panyaza Lesufi, later opened the state-of-the-art Booysens magistrate's court.
The court, which is equipped with a fully-fledged sexual offences wing, will offer a range of services.
It is also fully equipped with children-friendly consulting rooms to support the victims of gender-based violence.