Tottenham Hotspur have sacked manager Nuno Espirito Santo, the Premier League club announced on Monday, after a 3-0 home loss to Manchester United at the weekend left the London side eighth in the table.

Spurs had topped the Premier League standings in August after winning their opening three games but lost for the fifth time in the league to now sit 10 points behind leaders Chelsea.

Nuno's coaching staff have also been relieved of their duties.

The club have not yet announced a replacement.

"I know how much Nuno and his coaching staff wanted to succeed and I regret that we have had to take this decision," Spurs' managing director of football Fabio Paratici said in a statement.

"Nuno is a true gentleman and will always be welcome here. We should like to thank him and his coaching staff and wish them well for the future."

Nuno was appointed as Jose Mourinho's permanent replacement on a two-year deal in the close season after impressing during his four campaigns at Wolverhampton Wanderers.

He had a bright start, beating champions Manchester City on the opening day, but their season unravelled after defeats in four London derbies.

The 3-0 loss to United without a single shot on target had Spurs fans booing Nuno and chanting, "You don't know what you're doing".

Spurs, Uefa Champions League finalists in 2019, have also struggled in the Europa Conference League -- Uefa's new third-tier competition.

They sit third in their group, behind Rennes and Vitesse Arnhem, with only one win from three games ahead of their next fixture against Vitesse on Thursday.