1975 - Tutu becomes the first Black Anglican Dean of Johannesburg.
1980 - As general secretary of the South African Council of Churches, Tutu leads a delegation of church leaders to Prime Minister PW Botha, urging him to end apartheid. Although nothing comes of the meeting it is a historical moment where a Black leader confronts a senior white government official. The government confiscates Tutu's passport.
1984 - Tutu is awarded the Nobel Peace Prize for his efforts to bring about the end of white minority rule.
1985 - Tutu becomes the first Black Bishop of Johannesburg. He publicly endorses an economic boycott of South Africa and civil disobedience as a way to dismantle apartheid.
1986 - Tutu becomes the first Black person appointed as Bishop of Cape Town and head of the Anglican Church of the Province of Southern Africa. With other church leaders he mediates conflicts between Black protesters and government security forces.
1990 - State President FW de Klerk unbans the African National Congress (ANC) and announces plans to release Nelson Mandela from prison.
1991 - Apartheid laws and racist restrictions are repealed and power-sharing talks start between the state and 16 anti-apartheid groups.
1994 - After Mandela sweeps to power at the helm of the ANC in the country's first democratic elections, Tutu coins the term "Rainbow Nation" to describe the coming together of various races in post-apartheid South Africa.
1994 - Mandela asks Tutu to chair the Truth and Reconciliation Commission that was set up to listen to, record and in some cases grant amnesty to perpetrators of human right violations under apartheid.
1996 - Tutu retires from the church to focus solely on the commission. He continues his activism, advocating for equality and reconciliation and is later named Archbishop Emeritus.
1997 - Tutu is diagnosed with prostate cancer. He has since been hospitalised to treat recurring infections.
2011 - The Dalai Lama inaugurates the annual Desmond Tutu International Peace Lecture but does so via satellite link after the South African government denies the Tibetan spiritual leader a visa to attend.
2013 - Tutu makes outspoken comments about the ANC. He says he will no longer vote for the party because it had done a bad job addressing inequality, violence and corruption.
2013 - Dubbed "the moral compass of the nation", Tutu declares his support for gay rights, saying he would never "worship a God who is homophobic".
2021 - A frail-looking Tutu is wheeled into his former parish at St George's Cathedral in Cape Town, which used to be a safe haven for anti-apartheid activists, for a special thanksgiving service marking his 90th birthday.
Dec. 26, 2021 - Tutu dies in Cape Town, aged 90.