Initial reports suggested several people were in critical condition and about 44 other people had minor to serious injuries.
Mckenzie said two trucks — one a tanker carrying a hazardous chemical — were involved in the crash, as well as a bus and a light motor vehicle.
Though the blaze had been contained, the tanker was still smouldering and the heat from the fire was what was stopping the southbound lane from flowing.
Road Traffic Management Corporation provincial spokesperson Zinhle Mngomezulu said traffic towards Durban had been diverted at Midway and towards Johannesburg at the R103.
Meanwhile social media is reacting to the crash: