Moses Okori, leader of the local charity Integrated Community Agriculture and Nutrition (ICAN), said he knew of at least 22 people who had died of hunger this month in Kotido, another district in the region.
The United Nations World Food Programme (WFP) last month said at least 518,000 people, or 40% of the region's population, were facing high levels of food insecurity.
Local legislator Faith Nakut estimated that at least 600 people had died of hunger in the region since early June.
A spokesman for the Prime Minister's office, Julius Mucunguzi, said he had received reports of hunger-related deaths but was unable to give an exact toll.
The government dispatched trucks of food to the region last week, he said.