The rural town of Wartburg, outside Pietermaritzburg, will host the Confederation of African Cycling (CAC) Road Cycling Championships from February 9 to 14, Cycling SA said on Tuesday.
It will be the first time South Africa has hosted the continental road cycling showcase event.
"The local community is very accommodating and welcoming," event director Alec Lenferna said.
"Everyone from the marshals to the traffic police and the city officials now fully understand the road cycling events, which will make it logistically easier to organise."
The three days of time trial and three days of road racing will follow immediately after the SA Road Championships in Mbombela, providing a fortnight of opportunity for elite road cyclists to earn Olympic qualifying points.
The time trial and road races, contested among 26 African nations, will consist of 24km and 42km laps between Wartburg and Harburg to stage the elite, under-23 and junior races for men and women.