The Malawian, who is guided in South Africa by female manager Jodi Solomon, returns to action after failing in his attempt to oust Sergey "Frusher" Kovalev as the WBA Super, IBF and WBO light heavyweight champion in Russia on July 11.
Interestingly, Chilemba's bout against inexperienced Gvozdyk at T-Mobile Arena on November 11 will be on the same bill where Kovalev will defend against American Andre Ward.
The 29-year-old from Blantyre said: "I'm grateful to be on this HBO card. I'm up against unbeaten fighter Oleksandr Gvozdyk who is a good fighter.
"He has a good amateur background and he is a highly rated fighter. Pressure is on me, I know I'm going in with everything to lose but very little to gain."
Gvozdyk, who has 11 wins from as many boxing matches, is rated No 4 by the WBC, ninth by WBO and 10th by IBF.
Chilemba has 24 wins in 30 bouts. The former ABU and IBO super middleweight, WBO Africa, ABU, WBC International light heavyweight holder, is rated No 10 by the WBC.
He said he would work with Roy Jones Junior who is one of the best pound-for-pound boxers of all time for his fight against Gvozdyk.
"He is my idol, a person I always looked up to and can learn from," said Chilemba of the American who was the undisputed light heavyweight champion in 1999 by unifying the WBA, WBC and IBF titles.
Jones also held the WBA heavyweight strap in 2003, becoming the first former middleweight champion to win a heavyweight title in 106 years.
"It will be awesome and a huge opportunity for me to train with him and have him in my corner. Not only that he is the greatest, but he seems to care and has lots of love for the game."
Chilemba paid tribute to Main Events boss Kathy Duva, HBO, his manager Solomon, his fans and all boxing followers around the globe.
"I'm look forward to doing what I should have done against Kovalev," he said.