Number-one ranked Australia issued a statement of intent on Monday when they crushed Zimbabwe by 198 runs in the series opener.
Australia showed Zimbabwe no respect in hammering 147 runs in the final 10 overs to rack up 350 for six on a slow wicket, proving that their big-hitting middle order can be particularly difficult to contain.
However, with the dry, late winter pitches in Harare suiting the spinners more than the fast bowlers, the Proteas could have an advantage.
Leg-spinner Imran Tahir and left-arm spinner Aaron Phangiso both picked up regular wickets against Zimbabwe while conceding less than four runs per over, and also have the support of JP Duminy's off-spin.
"The wicket in Harare is a lot slower so it might be a strategy that we might try and use," Duminy said of the spin factor.
Fast bowlers Dale Steyn and Morne Morkel have returned to the SA squad after they were rested for the bilateral series against Zimbabwe, setting up the tantalising spectacle of the world's two fastest bowling attacks going head-to-head.