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Their African Confederation Cup third round, first leg match (kickoff 7pm) will be played behind closed doors at the Air Defence Stadium in the Egyptian capital from which fans have been banned after a series of recent violent outbreaks.
United have marched with efficient ease into the third round, overcoming both Congolese and Angolan opposition, but the Egyptians will be much more cagey opponents.
ENPPI are among the frontrunners in the Egyptian league this season, which restarted in January after a one-year hiatus.
The Pretoria outfit, who arrived in Cairo on Wednesday, will rely on the likes of Kermit Eramus to dispose of ENPPI.
Coach Gavin Hunt is revelling in the challenge of testing his tactical acumen against different styles of football and will seek to play his strongest side, although the likes of Bradley Grobler and Simba Sithole are not registered for the competition.
Sibusiso Zuma and Prince Hlela were left at home because they are suspended.
Zuma was the star of the last Confederation Cup win over Petro Atletico of Angola at Atteridgeville in Pretoria a fortnight. "I love playing in African competition, it is the ultimate test for any coach," Hunt said.