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Huge setback as Aids 'infection blocking' gels fails

By Sam Lister | Dec 15, 2009 | COMMENTS [ 0 ]

EFFORTS to create a drug that can protect people against HIV will suffer a significant setback today with the announcement that the leading "infection blocking" gel has failed in a trial of more than 9000 women.

Scientists will confirm this morning that the microbicide PRO 2000, a gel which is applied internally, does not stop HIV from entering the bloodstream. The findings, from the largest trial of its kind, are a serious blow to the development of a microbicide and to wider Aids research. With a scientific consensus growing that an Aids vaccine is many years away - despite promising results from a recent trial in Thailand - microbicides had been considered a more realistic drug strategy to protect people against HIV infection.

Earlier this year a preliminary trial involving PRO 2000 suggested that the gel might reduce chances of women contracting HIV by almost a third. The four-year international collaboration led by British scientists and funded by the government and the Medical Research Council confirms that the early finding was simply the result of chance.

Microbicides are formulated as gels or creams designed to destroy bacteria and viruses or to reduce their ability to establish an infection. The gel is applied to the vagina or rectum before sex to kill HIV, to prevent the virus entering human cells and to inhibit HIV replication.

The trial took place between 2005 and 2009 and was carried out by the Microbicides Development Programme, a partnership of 16 African and European research institutions.

The gel was given to participants along with free condoms, counselling for "safer sex negotiation" and sexual health advice.

Sheena McCormack, the chief investigator from the MRC, said the trial showed conclusively that PRO 2000 is of no added benefit and that it ended scientific speculation about its clinical importance. To date, no microbicide has been shown to be effective against HIV infection.

McCormack said: "It is a clear answer, and in that respect it shows a clear path forward. We need to find a better, more radical approach to preventing infection."

The result was particularly disheartening given the positive indications from the earlier trial, which was funded by the US National Institutes of Health and involved 3000 women. "Nevertheless it shows clearly the need to undertake trials which are large enough to provide definitive evidence for whether or not a product works," McCormack said.


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