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Male circumcision definitely reduces the risk of HIV infection, researchers at the SA Cochrane Centre announced yesterday.
The centre had previously held that there was not enough evidence to recommend circumcision as an intervention.
"Research on the effectiveness of male circumcision in preventing HIV in heterosexual men is conclusive," said lead researcher Nandi Siegfried, co-director of the centre at the SA Medical Research Council.
"No further trials are required to establish that HIV infection rates are reduced in heterosexual men for at least the first two years after circumcision."
She said policy makers could now consider using circumcision as an additional tool in HIV prevention programmes.
The Cochrane Collaboration is a highly-respected international network of researchers that seeks to improve health care decision-making through systematic reviews of the effects of health care interventions such as circumcision.
Siegfried said three recent African trials supported the conclusion that circumcision reduced HIV risk.
"After including new data from these trials in their review, Cochrane researchers have changed their previous conclusions that there was insufficient evidence to recommend circumcision to prevent HIV infection in heterosexual men."
Previous studies had investigated the association between circumcision and HIV, but until now, Cochrane researchers had been unable to strongly recommend circumcision because of the lack of high quality evidence.
Siegfried said circumcision might help to protect against HIV by removing cells in the foreskin to which the virus was specifically attracted. These Langerhans cells had receptors that enabled the virus to enter them.
The results show that circumcision in heterosexual men reduced their risk of acquiring HIV by an average 54percent over a two year period, compared with uncircumcised men. - Sapa