Road accidents kill at least 20 children a month in South Africa.
The child accident prevention foundation at the Red Cross Children's Hospital is using this road safety week to promote the use of seatbelts by vulnerable children in motor vehicles.
The campaign is part of the first UN global road safety week, which started on Monday and will run until Saturday.
This initiative focuses on young road users.
"According to the medical research council, passenger deaths in children are the fourth leading cause of deaths in our country, not to mention all the children that suffer injuries and disabilities on a daily basis," said Nelmarie du Toit, the foundation's spokesman.
She said recent national statistics show that 84percent of children travel in cars without wearing seat belts.
According to Du Toit, the Red Cross Children's Hospital alone treats at least 20 children a month nationally for injuries sustained in motor vehicle collisions.
"Various activities will take place at the hospital to promote the use of seatbelts and child car safety seats.
"Schools, colleges and universities will also be targeted with promotional materials urging drivers and passengers to buckle up," said Du Toit.