Teenage pregnancy, violence in schools and HIV-Aids orphans will be discussed when the Caring Schools Network (Casnet) meets this week in Johannesburg.
The network, launched in 2005, comprises education, health and child-rights organisations.
They will debate ways in which communities can give care and support to vulnerable children.
Lynette Mudekunye, of Save the Children, which is part of Casnet, said that vulnerable children were not limited to orphans.
She said a supportive environment was crucial in schools.
The meeting will define what a caring school should be and how it can make a difference in solving growing problems such as teenage pregnancies and school violence.
"We will come up with one goal so that organisations don't work to achieve the same thing from opposite sides," Mudekunye said.