Model, actress and radio personality Pearl Thusi was in a car accident that left her and her daughte.
"He leaves a tremendous legacy and I think for the young people that have watched him and followed him..., this is a time for them to say 'I potentially could be the next Vuyo'..., somebody who is completely fearless," Mokhobo said in a Morning Live interview with Leanne Manas.
"He was somebody who was so dedicated and professional. It didn't matter what it was, if Vuyo had to do it, he did it with absolutely the best of his ability," Mokhobo said.
Manas broke down and cried on camera at the start of the programme on Monday.
The SABC reported that Mbuli, 46, collapsed while watching a rugby match between the Cheetahs and the Reds at the Free State Stadium on Saturday night.
He was treated at the scene before being taken to the Bloemfontein Mediclinic, where he later died.
Mokhobo said a memorial service would be held at the SABC on Wednesday, and that the Mbuli family had informed the broadcaster that his funeral would be held on Friday.
Details of the two events would be released later in the week.