Born in Hammarsdale in KwaZulu-Natal, Sithole currently stars in e.tv's soapie Scandal! as Ndumiso, an ambitious young man who comes to Johannesburg hoping to achieve success.
After spending many years acting on stage, Sithole felt he was ready for the small screen.
The 26-year-old was fortunate to kick-start his television career with a role on TV's biggest shows and has had to adjust the loudness of his voice as he synchronises with camera angles.
"I wanted to expand my career profile and grow as an actor. But most importantly, I was looking at TV because it pays better. I decided to give stage a break but I will go back when I get a chance," he explains.
Sithole believes that Ndumiso is more or less like him because he is ambitious and married, just like him.
In the soapie, Ndumiso has just got married to Gontse (Khanyisile Zwane), the mother of his child, despite their rocky relationship.
Ndumiso has been a naughty boy, fooling around with another girl behind Gontse's back.
Sithole explains that Ndumiso and Gontse's marriage will bring viewers the challenges in marriage.
Sithole warns viewers of the drama between him and his mother-in-law Gloria (Marjorie Langa) when she decides to move in with the newlyweds.
"This will actually infuriate Ndumiso because Gloria will interfere in their lives as they learn to understand each other."
Sithole, a staunch member of Ebuhleni Nazareth, a faction of the Shembe Church, has a show called Inhlalisuthi Nobunazarethi Ebuhleni on Unyazi TV on OpenView HD. The show is about balancing culture and religion.
"The show is important because it has a lot of information about important issues that many people did not know. It seeks to show the relationship between religion and culture.
"It educates men, especially those who are hungry to know about their culture."
Sithole started acting in school dramas when he moved to Mpola in Marianhill, west of Dueban. He then began doing community theatre, performing at various city halls. He wrote, directed and acted in many plays that include Crime Doesn't Pay. He graduated from community theatre to professional stage theatre where he performed at Kwasuka Theatre in Durban. His biggest wish is to star in films and drama series.