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The 47-year-old comedian - who has daughters Lola Simone, 10, and
eight-year-old Zahra Savannah with his wife Malaak Compton-Rock - is in
favour of making marijuana legal in the US because he believes it is
ultimately a harmless drug.
Chris insists comic star Seth Rogen - a prolific weed smoker who was named Stoner of the Year in February - is proof you can be a cannabis user and have a successful life.
In an interview with Vanity Fair magazine, he said: "I'm all for the legalisation of weed. I have two daughters, but we all know that alcohol is worse and legal. Seth Rogen is a productive member of society. Mel Gibson has a problem."
The '2 Days in New York' star also spoke about how his life as a stand-up comedian isn't as fun as it used to be now he has achieved many of goals.
Chris - who has starred in numerous films including the 'Madagascar' animated movie series - says he now has to work a lot harder to keep up his career momentum.
When asked whether his outlook on his career had changed over time, he said: "It was more fun. First of all, you had three goals: to get good at comedy, to make money from comedy, and to get laid from comedy. What do we do now?
"Well, people seem to think we're good. We have money. We're married, so the whole working to get laid thing is over. Sad to say, but we work now to maintain our lifestyles, to not suck, and to avoid 'Celebrity Apprentice'."